Experimental allergic encephalomyelitis eae
実験的自己免疫性脳脊髄炎（じっけんてきじこめんえきせいのうせきずいえん、Experimental autoimmune encephalomyelitis, EAE）は、脳炎の動物実験モデルである。実験的アレルギー性脳脊髄炎 (Experimental allergic encephalomyelitis, EAE) と称されることもある。このモデルは中枢神経系の炎症性脱髄疾患である。実験動物に他の動物の中枢神経組織由来のタンパク質などを接種することで、ミエリン蛋白に特異的なT細胞を誘導し、自己免疫性の脳脊髄炎を発症させ … WebOverview Fingerprint Abstract Adoptively-transferred experimental allergic encephalomyelitis (EAE) was induced in the SWR (H-2 q) strain of mouse using lymph node cells, spleen cells, or cell lines sensitized to whole myelin basic protein (MBP).
Experimental allergic encephalomyelitis eae
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Webas experimental allergic encephalomyelitis (EAE), must address our present state of knowledge about MS. MS is a complicated disease, the cause and pathogenesis of which are incompletely understood. Though we have made progress in therapy of MS, treatment is imper-fect. Current therapies reduce the frequency of relapse, WebHere we provide quantitative evidence that blood-brain barrier leakage is an early event and precedes massive cellular infiltration in the development of acute experimental allergic …
WebExperimental allergic encephalomyelitis (EAE): Delayed myelination-inhibition in vitro with EAE-serum: Changes in vulnerability of oligodendroglia and newly formed myelin sheaths Jürg Ulrich & Murray B. Bornstein Acta Neuropathologica 25 , 138–148 ( 1973) Cite this article 40 Accesses 13 Citations Metrics Summary WebThe association between myelin basic protein (BP) and experimental allergic encephalomyelitis (EAE) has been long and intimate. A purified well-characterized antigen was essential for studies of pathogenesis, and the existence of BP was not even suspected until a search for the causative agent of EAE was undertaken. 1–3 In spite of the …
WebExperimental allergic encephalomyelitis (EAE) has been used for years as an experimental model of MS. It can be induced in mice, rats and guinea pigs by intradermal injection of whole CNS tissue or myelin basic protein (MBP). Two weeks after the injection, the experimental animals develop ascending paralysis. WebIn experimental allergic encephalomyelitis (EAE), autoimmune T cells infiltrate the central nervous system (CNS) and initiate demyelinating …
WebFeb 25, 2013 · Studies in experimental allergic encephalomyelitis (EAE), histopathological studies of MS lesions, and immunologic markers in serum and cerebrospinal fluid of MS patients suggest that MS is an...
WebSep 19, 2005 · Experimental allergic encephalomyelitis (EAE) serves as a model for multiple sclerosis and is considered to be a CD4 + Th1 cell–mediated autoimmune disease. tashbih name meaningWebNov 16, 2006 · Active induction of experimental allergic encephalomyelitis Introduction. Multiple sclerosis (MS) is an inflammatory, … 鯨 脂身 レシピWebExperimental allergic encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system (CNS) which has many clinical and pathological features in … tashbih and tanzihWebexperimental allergic encephalomyelitis: a demyelinating allergic encephalomyelitis produced by the injection of brain tissue, usually with an adjuvant. Synonym(s): … tashbir nepalWebCigarette smoking increases the risk of MS in an HLA-dependent fashion, but the underlying mechanisms remain unknown. Here, we explored the effect of cigarette smoke exposure … tashbih tamsilWebThe costimulatory CD40L–CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly expressed on MHCII+ B cells, dendritic cells and macrophages in human MS lesions. Here we investigated ... 鯨 給食 いつまで 東京WebExperimental autoimmune encephalomyelitis (EAE) is a model of the neuroimmune system responding to priming with central nervous system (CNS)-restricted antigens. It is an excellent model of... tashbunny