Greater than dose proportional
WebJun 18, 2007 · The results of this study indicate that plasma AUC0−∞ increased in a dose-proportional manner over the 25–400 mg dose range. Over the same dose range, plasma Cmax increased in a greater than dose-proportional manner and C24 h increased in a modestly less than dose proportional manner. WebA greater than dose proportional increase in area under the concentration-time [...] curve (AUC) and the observed maximum serum concentration (Cmax) was observed in the …
Greater than dose proportional
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WebSep 6, 2024 · Of the three drugs, 23 - 25 two exhibited nonlinear pharmacokinetics: letermovir had greater than dose proportional pharmacokinetics and eliglustat had nonlinear, greater than expected accumulation upon multiple-dose administration. Additionally, one study was conducted in patients with cancer (gilteritinib). WebApr 13, 2024 · A Cox proportional hazard model showed that patients with a class I mHA count greater than the population median had an increased hazard of GvHD mortality (hazard ratio [HR] ... A multi-mHA analysis in an HLA haplotype shows a dose–response relationship between the number of mHAs present (0–2) and the hazard for various …
WebThe V D of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma. V D is directly proportional with the amount of drug distributed into tissue; a higher V D indicates a greater amount of tissue distribution. WebBoth the maximal plasma concentration (C max ) and the AUC from 0 h to infinity (AUC 0 -) were dose proportional, as shown in Fig. 4. Safety data. Inhalation of capreomycin was not associated with ...
WebMay 1, 2024 · VIS649 exposure increased in a greater than dose-proportional manner. At the higher tested doses (6.0 and 12.0 mg/kg), serum VIS649 concentrations were biexponential, with a rapid distribution phase followed … WebFor the clinical dose range of 150 â 300 mg, increases of 2.3- and 2.6-fold were observed for AUC and C(max), respectively. All doses of aliskiren were well tolerated. …
WebDec 1, 2024 · Dextromethorphan when co-administered with bupropion displays nonlinear pharmacokinetics at steady state, with greater than dose-proportional changes in AUC and C max for varying doses of dextromethorphan [60 to 120 mg (0.67-1.33 times the maximum recommended dose of Auvelity)] and less than dose-proportional changes …
WebApr 13, 2024 · 1) First -order elimination: drug assumed to rapidly equilibrate into volume of distribution; plasma concentrations decline according to first-order kinetics; elimination rate from plasma is proportional to plasma concentration, fraction eliminated per unit time is elimination rate constant (k el ). dCp dt = − kelCp Cp = C0e − kelt small affordable prefab homes coloradoWebTreating dose as a continuous, rather than a categorical variable, requires a mathematical model. Smith et al. proposed that to establish dose proportionality, the 90% CI for the … solid oak toilet seat brass fittingsWebEarly clinical data suggested greater than dose proportional increases in exposure following oral administration. The aim of the present studies was to definitively characterize the oral and IV dose proportionality of telcagepant. Methods. Healthy adult subjects were enrolled in two separate open-label randomized dose proportionality studies: solid oak trunk coffee tableWebDiagnostic imaging using CT occurs in more than a third of acute care hospitalizations in the U.S. (Vance, 2013) and greater than 90 million scans are performed annually in the U.S. (IMV, 2024 ). ... As radiation dose is known to be directly related and proportional to future cancer risk (Board of Radiation Effects, 2006; Berrington de Gonzalez ... solid oak toy boxWebDextromethorphan when co-administered with bupropion displays nonlinear pharmacokinetics at steady state, with greater than dose-proportional changes in AUC and c max for varying doses of dextromethorphan [60 to 120 mg (0.67-1.33 times the maximum recommended dose of AUVELITY)] and less than dose-proportional … solid oak television cabinetWebthan dose proportionally and this trend was more pronounced for C. max (Table 9) It is speculated that the less-than-dose-proportional increase of naproxen exposure is … solid oak wall panellingWebMar 26, 2024 · Stable dose The median stable dose was 7 g/night and ranged from 4 to 9 g/night, or 69.8 to 225.8 mg/kg/night. Plasma concentrations at stable dose SXB plasma concentrations were generally greater after dose 2 compared with dose 1 for the equivalent postdose time points ( Figure 2 ). solid oak wall cabinet