WebJun 1, 2024 · It emerges that PTB depletion unlocks the potential of astrocytes to convert … WebQian et al. reported that inhibition of RNA-binding protein PTB results to conversion midbrain astrocytes to dopaminergic neurons which provide axons to reconstruct the nigrostriatal circuit. Moreover, re-innervation of striatum is accompanied by restoration of dopamine levels and rescue of motor deficits in PD mice model.

Targeting PTB as a One-Step Procedure for In Situ Astrocyte-to …

WebFeb 5, 2024 · The neuronal conversion of cortical astrocytes can be fulfilled by a simple supplement of insulin in the medium. Furthermore, the astrocytes from other brain regions such as hippocampus and... WebHere we report an efficient one-step conversion of isolated mouse and human astrocytes to functional neurons by depleting the RNA-binding protein PTB (also known as PTBP1). Applying this approach to the mouse brain, we demonstrate progressive conversion of astrocytes to new neurons that innervate into and repopulate endogenous neural circuits. tejas birria buda tx

Method to combat Parkinson’s disease by astrocyte-to-neuron conversion

WebSole PTB knockdown is able to increase expression of miR-124 and miR-9, as well as … WebWe recently develop an efficient single-step strategy to convert isolated mouse and human astrocytes into functional neurons by depleting the RNA binding protein PTB in isolated astrocytes in culture and directly in mouse brain. We show progressive conversion of astrocytes into new neurons that can innervate into endogenous neural circuits. WebNational Center for Biotechnology Information tejas buyers