WebApr 13, 2024 · Signal regulatory protein alpha (SIRPα) is a transmembrane protein expressed on all myeloid cells, including monocytes, macrophages, and neutrophils. … http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM8649784
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WebMar 1, 2009 · On macrophages, for example, SIRPα (signal regulatory protein-α) is a checkpoint receptor that binds the ubiquitously expressed protein CD47, 9, 10, 36,56 … WebJun 7, 2024 · Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that …
Webアズワンの【AXEL】85-7748-04 SIRPA (BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP, Tyrosine-protein Phosphatase Non-receptor Type Substrate 1, Brain Ig-like Molecule with Tyrosine-based Activation Motifs, CD172 Antigen-like Family Member A, Inhibitory Receptor SHPS-1, Macrophage Fusion Receptor, MyD-1 Antigen, Signal-regulatory Protein alpha-1, Signal … WebCytoplasmic localization of calcium/calmodulin-dependent protein kinase I-α depends on a nuclear export signal in its regulatory domain (PDF) Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-α depends on a nuclear export signal in its regulatory domain Marina Picciotto - Academia.edu
WebCD47 is expressed on all hematopoietic cells, including leucocytes, platelets, and erythrocytes except for Rh-negative erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts, and many tumor cell lines. CD47 binds to and activates the inhibitory Signal regulatory protein α (SIRPα) expressed on phagocytic cells. WebCD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member …
Webprotein kinase, cAMP dependent regulatory, type II alpha focal adhesion, cytoplasm, soluble fraction, transferase activity, nucleotide binding, insoluble fraction, kinase activity, signal transduction, phosphorylation, protein binding, protein complex, perinuclear region of cytoplasm, membrane, plasma membrane, protein homodimerization activity, protein …
WebIntegrin-associated protein (CD47) is a receptor for the cell-binding domain of thrombospondin (TSP) family members, a ligand for the transmembrane signaling protein … cysteamine pillsWebRGS20 (regulator of G protein signaling 20), RGS9BP (RGS9-binding protein), FGB (fibrinogen beta chain) and INA (alpha-internexin) were mRNAs in the feature subset of the SVM classifier. According to the ceRNA network ( Figure 2C ), two miRNA-mRNA pairs and an lncRNA-miRNA-mRNA triplet were formed among these prognosis related RNAs, … cysteamine solubilityWebApr 13, 2024 · Accumulation of the misfolded synaptic protein α-synuclein (αSyn*) is a hallmark of neurodegenerative disease in Parkinson's disease (PD). Recent studies … bind benefits health insuranceWebJan 15, 2024 · Signal regulatory protein alpha (SIRPα) is a transmembrane protein, activating Src-homology-2 domain-containing protein tyrosine phosphatase 1/2 (SHP-1/2) … cysteamine thioglycolateWebMar 19, 2024 · Signal regulatory protein α (SIRPα), an IgSF family member with 2 immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in the cytoplasmic tail, plays an … bind band bondSignal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons. SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don't eat me" signal. This interaction … See more The cytoplasmic region of SIRPα is highly conserved between rats, mice and humans. Cytoplasmic region contains a number of tyrosine residues, which likely act as ITIMs. Upon CD47 ligation, SIRPα is phosphorylated and … See more SIRPα recognizes CD47, an anti-phagocytic signal that distinguishes live cells from dying cells. CD47 has a single Ig-like extracellular domain and five membrane spanning regions. The interaction between SIRPα and CD47 can be modified by endocytosis or … See more • Oldenborg PA (2013). "CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease". … See more The extracellular domain of SIRP α binds to CD47 and transmits intracellular signals through its cytoplasmic domain. CD47-binding is mediated … See more Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. In one study, they engineered high-affinity variants of SIRP α that antagonized CD47 on cancer cells and caused increase phagocytosis of cancer cells. Another study … See more bind bathroom tileWebFeb 21, 2024 · 30 Signal Regulatory Protein Alpha (SIRPα) V1/V1 homozygous patients with 2nd line recurrent/metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) who had received prior platinum-based therapy within the recurrent/metastatic setting. Drug: … bind beauty